LymphedemaV1, France, Analysis, bibRecord, 000110

Radiotherapy associated with concurrent bevacizumab in patients with non-metastatic breast cancer.

Identifieur interne : 000110 ( France/Analysis ); précédent : 000109; suivant : 000111

Radiotherapy associated with concurrent bevacizumab in patients with non-metastatic breast cancer.

Auteurs : Victor Pernin [France] ; Lisa Belin [France] ; Paul Cottu [France] ; Patrick Bontemps [France] ; Claire Lemanski [France] ; Brigitte De La Lande [France] ; Pierre Baumann [France] ; Fernand Missohou [France] ; Christelle Levy [France] ; Karine Peignaux [France] ; Pierre Bougnoux [France] ; Fabrice Denis [France] ; Marc Bollet [France] ; Rémi Dendale [France] ; Nora Ady Vago [France] ; François Campana [France] ; Alain Fourquet [France] ; Youlia M. Kirova [France]

Source :

Breast (Edinburgh, Scotland) [ 1532-3080 ] ; 2014.

RBID : pubmed:25260760

Descripteurs français

English descriptors

KwdEn :
- Adult, Aged, Angiogenesis Inhibitors (adverse effects), Antibodies, Monoclonal, Humanized (adverse effects), Bevacizumab, Breast Neoplasms (pathology), Breast Neoplasms (therapy), Carcinoma, Ductal, Breast (pathology), Carcinoma, Ductal, Breast (therapy), Carcinoma, Lobular (pathology), Carcinoma, Lobular (therapy), Chemoradiotherapy, Adjuvant (adverse effects), Dermatitis (etiology), Dyspnea (etiology), Esophagitis (etiology), Female, Fibrosis, Humans, Lymphedema (etiology), Middle Aged, Neoadjuvant Therapy, Prospective Studies, Radiation Injuries (etiology), Radiation-Sensitizing Agents (adverse effects), Skin (pathology), Telangiectasis (etiology).
MESH :
- chemical , adverse effects : Angiogenesis Inhibitors, Antibodies, Monoclonal, Humanized, Radiation-Sensitizing Agents.
- adverse effects : Chemoradiotherapy, Adjuvant.
- etiology : Dermatitis, Dyspnea, Esophagitis, Lymphedema, Radiation Injuries, Telangiectasis.
- pathology : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Skin.
- therapy : Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular.
- Adult, Aged, Bevacizumab, Female, Fibrosis, Humans, Middle Aged, Neoadjuvant Therapy, Prospective Studies.

Abstract

The purpose of this multicenter prospective and descriptive study was to determine late toxicities and outcomes among patients with non-metastatic breast cancer receiving concurrent bevacizumab (BV) and radiation therapy (RT) in the clinical trials. Early and late toxicities were assessed and evaluation was available for 63 patients (pts) at 12 months. Acute radiation dermatitis was observed in 48 (76%): grade 1 for 27, grade 2 for 17 and grade 3 for 4 pts. Grade 2 acute oesophagitis was observed in one patient (2%). Little toxicity was described 1 year after the completion of RT: 7 pts (12%): grade 1-2 pain, 3 (5%) presented grade 1 fibrosis, and 2 pts (4%) - telangiectasia. One patient (2%) experienced grade 1 dyspnoea. Five grade 1-2 lymphoedema occurred. Only one patient experienced a LEVF value less than 50% one year after the end of RT. In conclusion, the concurrent BV with locoregional RT provides acceptable toxicities.

DOI: 10.1016/j.breast.2014.08.015
PubMed: 25260760

Affiliations:

Links to Exploration step

pubmed:25260760

Le document en format XML

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<author><name sortKey="Dendale, Remi" sort="Dendale, Remi" uniqKey="Dendale R" first="Rémi" last="Dendale">Rémi Dendale</name>
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<author><name sortKey="Vago, Nora Ady" sort="Vago, Nora Ady" uniqKey="Vago N" first="Nora Ady" last="Vago">Nora Ady Vago</name>
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<author><name sortKey="Campana, Francois" sort="Campana, Francois" uniqKey="Campana F" first="François" last="Campana">François Campana</name>
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<author><name sortKey="Fourquet, Alain" sort="Fourquet, Alain" uniqKey="Fourquet A" first="Alain" last="Fourquet">Alain Fourquet</name>
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<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Radiotherapy associated with concurrent bevacizumab in patients with non-metastatic breast cancer.</title>
<author><name sortKey="Pernin, Victor" sort="Pernin, Victor" uniqKey="Pernin V" first="Victor" last="Pernin">Victor Pernin</name>
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<author><name sortKey="Belin, Lisa" sort="Belin, Lisa" uniqKey="Belin L" first="Lisa" last="Belin">Lisa Belin</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Cottu, Paul" sort="Cottu, Paul" uniqKey="Cottu P" first="Paul" last="Cottu">Paul Cottu</name>
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<author><name sortKey="Baumann, Pierre" sort="Baumann, Pierre" uniqKey="Baumann P" first="Pierre" last="Baumann">Pierre Baumann</name>
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<author><name sortKey="Peignaux, Karine" sort="Peignaux, Karine" uniqKey="Peignaux K" first="Karine" last="Peignaux">Karine Peignaux</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Jean Bernard, Département de radiothérapie, 72000 Le Mans</wicri:regionArea>
<wicri:noRegion>72000 Le Mans</wicri:noRegion>
<wicri:noRegion>72000 Le Mans</wicri:noRegion>
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<author><name sortKey="Bollet, Marc" sort="Bollet, Marc" uniqKey="Bollet M" first="Marc" last="Bollet">Marc Bollet</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris</wicri:regionArea>
<wicri:noRegion>75005 Paris</wicri:noRegion>
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<region type="région" nuts="2">Île-de-France</region>
</placeName>
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<author><name sortKey="Dendale, Remi" sort="Dendale, Remi" uniqKey="Dendale R" first="Rémi" last="Dendale">Rémi Dendale</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris</wicri:regionArea>
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<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vago, Nora Ady" sort="Vago, Nora Ady" uniqKey="Vago N" first="Nora Ady" last="Vago">Nora Ady Vago</name>
<affiliation wicri:level="1"><nlm:affiliation>Roche, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Roche</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Campana, Francois" sort="Campana, Francois" uniqKey="Campana F" first="François" last="Campana">François Campana</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris</wicri:regionArea>
<wicri:noRegion>75005 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fourquet, Alain" sort="Fourquet, Alain" uniqKey="Fourquet A" first="Alain" last="Fourquet">Alain Fourquet</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris</wicri:regionArea>
<wicri:noRegion>75005 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirova, Youlia M" sort="Kirova, Youlia M" uniqKey="Kirova Y" first="Youlia M" last="Kirova">Youlia M. Kirova</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris, France. Electronic address: youlia.kirova@curie.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Hospital, Radiotherapy Department, 75005 Paris</wicri:regionArea>
<wicri:noRegion>75005 Paris</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Breast (Edinburgh, Scotland)</title>
<idno type="eISSN">1532-3080</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Angiogenesis Inhibitors (adverse effects)</term>
<term>Antibodies, Monoclonal, Humanized (adverse effects)</term>
<term>Bevacizumab</term>
<term>Breast Neoplasms (pathology)</term>
<term>Breast Neoplasms (therapy)</term>
<term>Carcinoma, Ductal, Breast (pathology)</term>
<term>Carcinoma, Ductal, Breast (therapy)</term>
<term>Carcinoma, Lobular (pathology)</term>
<term>Carcinoma, Lobular (therapy)</term>
<term>Chemoradiotherapy, Adjuvant (adverse effects)</term>
<term>Dermatitis (etiology)</term>
<term>Dyspnea (etiology)</term>
<term>Esophagitis (etiology)</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Humans</term>
<term>Lymphedema (etiology)</term>
<term>Middle Aged</term>
<term>Neoadjuvant Therapy</term>
<term>Prospective Studies</term>
<term>Radiation Injuries (etiology)</term>
<term>Radiation-Sensitizing Agents (adverse effects)</term>
<term>Skin (pathology)</term>
<term>Telangiectasis (etiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux humanisés (effets indésirables)</term>
<term>Bévacizumab</term>
<term>Carcinome canalaire du sein ()</term>
<term>Carcinome canalaire du sein (anatomopathologie)</term>
<term>Carcinome lobulaire ()</term>
<term>Carcinome lobulaire (anatomopathologie)</term>
<term>Chimioradiothérapie adjuvante (effets indésirables)</term>
<term>Dermatite (étiologie)</term>
<term>Dyspnée (étiologie)</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Humains</term>
<term>Inhibiteurs de l'angiogenèse (effets indésirables)</term>
<term>Lymphoedème (étiologie)</term>
<term>Lésions radio-induites (étiologie)</term>
<term>Oesophagite (étiologie)</term>
<term>Peau (anatomopathologie)</term>
<term>Radiosensibilisants (effets indésirables)</term>
<term>Sujet âgé</term>
<term>Traitement néoadjuvant</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Télangiectasie (étiologie)</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Angiogenesis Inhibitors</term>
<term>Antibodies, Monoclonal, Humanized</term>
<term>Radiation-Sensitizing Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Chemoradiotherapy, Adjuvant</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome canalaire du sein</term>
<term>Carcinome lobulaire</term>
<term>Peau</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Chimioradiothérapie adjuvante</term>
<term>Inhibiteurs de l'angiogenèse</term>
<term>Radiosensibilisants</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dermatitis</term>
<term>Dyspnea</term>
<term>Esophagitis</term>
<term>Lymphedema</term>
<term>Radiation Injuries</term>
<term>Telangiectasis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
<term>Carcinoma, Lobular</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term>
<term>Carcinoma, Ductal, Breast</term>
<term>Carcinoma, Lobular</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dermatite</term>
<term>Dyspnée</term>
<term>Lymphoedème</term>
<term>Lésions radio-induites</term>
<term>Oesophagite</term>
<term>Télangiectasie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Bevacizumab</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Neoadjuvant Therapy</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Bévacizumab</term>
<term>Carcinome canalaire du sein</term>
<term>Carcinome lobulaire</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Humains</term>
<term>Sujet âgé</term>
<term>Traitement néoadjuvant</term>
<term>Tumeurs du sein</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The purpose of this multicenter prospective and descriptive study was to determine late toxicities and outcomes among patients with non-metastatic breast cancer receiving concurrent bevacizumab (BV) and radiation therapy (RT) in the clinical trials. Early and late toxicities were assessed and evaluation was available for 63 patients (pts) at 12 months. Acute radiation dermatitis was observed in 48 (76%): grade 1 for 27, grade 2 for 17 and grade 3 for 4 pts. Grade 2 acute oesophagitis was observed in one patient (2%). Little toxicity was described 1 year after the completion of RT: 7 pts (12%): grade 1-2 pain, 3 (5%) presented grade 1 fibrosis, and 2 pts (4%) - telangiectasia. One patient (2%) experienced grade 1 dyspnoea. Five grade 1-2 lymphoedema occurred. Only one patient experienced a LEVF value less than 50% one year after the end of RT. In conclusion, the concurrent BV with locoregional RT provides acceptable toxicities.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Bourgogne-Franche-Comté</li>
<li>Franche-Comté</li>
<li>Languedoc-Roussillon</li>
<li>Occitanie (région administrative)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Besançon</li>
<li>Montpellier</li>
<li>Paris</li>
<li>Saint Cloud</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Pernin, Victor" sort="Pernin, Victor" uniqKey="Pernin V" first="Victor" last="Pernin">Victor Pernin</name>
</region>
<name sortKey="Baumann, Pierre" sort="Baumann, Pierre" uniqKey="Baumann P" first="Pierre" last="Baumann">Pierre Baumann</name>
<name sortKey="Belin, Lisa" sort="Belin, Lisa" uniqKey="Belin L" first="Lisa" last="Belin">Lisa Belin</name>
<name sortKey="Bollet, Marc" sort="Bollet, Marc" uniqKey="Bollet M" first="Marc" last="Bollet">Marc Bollet</name>
<name sortKey="Bontemps, Patrick" sort="Bontemps, Patrick" uniqKey="Bontemps P" first="Patrick" last="Bontemps">Patrick Bontemps</name>
<name sortKey="Bougnoux, Pierre" sort="Bougnoux, Pierre" uniqKey="Bougnoux P" first="Pierre" last="Bougnoux">Pierre Bougnoux</name>
<name sortKey="Campana, Francois" sort="Campana, Francois" uniqKey="Campana F" first="François" last="Campana">François Campana</name>
<name sortKey="Cottu, Paul" sort="Cottu, Paul" uniqKey="Cottu P" first="Paul" last="Cottu">Paul Cottu</name>
<name sortKey="De La Lande, Brigitte" sort="De La Lande, Brigitte" uniqKey="De La Lande B" first="Brigitte" last="De La Lande">Brigitte De La Lande</name>
<name sortKey="Dendale, Remi" sort="Dendale, Remi" uniqKey="Dendale R" first="Rémi" last="Dendale">Rémi Dendale</name>
<name sortKey="Denis, Fabrice" sort="Denis, Fabrice" uniqKey="Denis F" first="Fabrice" last="Denis">Fabrice Denis</name>
<name sortKey="Fourquet, Alain" sort="Fourquet, Alain" uniqKey="Fourquet A" first="Alain" last="Fourquet">Alain Fourquet</name>
<name sortKey="Kirova, Youlia M" sort="Kirova, Youlia M" uniqKey="Kirova Y" first="Youlia M" last="Kirova">Youlia M. Kirova</name>
<name sortKey="Lemanski, Claire" sort="Lemanski, Claire" uniqKey="Lemanski C" first="Claire" last="Lemanski">Claire Lemanski</name>
<name sortKey="Levy, Christelle" sort="Levy, Christelle" uniqKey="Levy C" first="Christelle" last="Levy">Christelle Levy</name>
<name sortKey="Missohou, Fernand" sort="Missohou, Fernand" uniqKey="Missohou F" first="Fernand" last="Missohou">Fernand Missohou</name>
<name sortKey="Peignaux, Karine" sort="Peignaux, Karine" uniqKey="Peignaux K" first="Karine" last="Peignaux">Karine Peignaux</name>
<name sortKey="Vago, Nora Ady" sort="Vago, Nora Ady" uniqKey="Vago N" first="Nora Ady" last="Vago">Nora Ady Vago</name>
</country>
</tree>
</affiliations>
</record>

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Radiotherapy associated with concurrent bevacizumab in patients with non-metastatic breast cancer.

Radiotherapy associated with concurrent bevacizumab in patients with non-metastatic breast cancer.

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